He got me an interesting article about toxicity polypropylene. It is from an unnamed Czech site abo

Discussion on the impact of electronic cigarettes (vaping) on human health. This topic deserves a separate thread for a simple reason: the electronic cigarette is less harmful than a normal cigarette.
He got me an interesting article about toxicity polypropylene. It is from an unnamed Czech site about health. The site is designed primarily for professionals, ie doctors but they are there not say relevant information. But is not no diva-type page, and we are under. I wonder if there is among us a chemist or a doctor, or is what is written in the text of a fact or not and whether the text talks about the type of PG that we inhale or is it some other type? "Propylene glycol is a simple alcohol used in the chemical industry as not to cause Freezing preparation of liquid or as a material for manufacturing of paints, synthetic resins and plastics. Use has also in the food industry as a flavoring substance, emulsifying and preservative. Is represented in a number of cosmetic masterskaya preparations such as for example, certain shampoos, masterskaya conditioners, lotions, creams, etc.. Finally, a propylene masterskaya glycol used in the pharmaceutical industry as a vehicle for solubilizing hydrophobic drugs for topical, oral and parenteral administration. follows that human exposure masterskaya to this compound is quite significant, as the of course, carries the risk of possible side effects. With this in fact is not recommended to exceed the World Health Organization daily intake of propylene glycol and 25 mg / kg body weight. Propylene glycol is found in some pharmacological preparations, such as in Dermatology Topical corticosteroids, antifungals , antibiotics and chemotherapeutics, anesthetics and anticonvulsants intended for short-term oral or parenteral administration. Considering the potential toxicity masterskaya of propylene glycol as a very serious fact it appears that the indicated daily allowable value of 25 mg of propylene glycol per kg of body weight, for example, resides in neurological indications anesthetic or very significantly exceeded. toxic effects of propylene glycol were first time described in 1952, in the form of a skin allergy. since been published The number of cases and studies describing the occurrence of contact dermatitis, and local irritation of the skin and mucosa after administration of medicinal products containing propylene glycol. many significant overall metabolic effects of topical administration of creams containing propylene glycol reported in affected boluses with burns. Among the most serious masterskaya systemic side effects included an increase in serum osmolality as a result of the transdermal absorption of osmotically active molecules of propylene glycol. similarly been described after topical application of cream containing propylene glycol as the development of nephrotic syndrome masterskaya and coma. The incidence masterskaya of serious adverse effects of propylene glycol occurs most often after the overall administration of the preparation containing the compound. biological half-life of propylene glycol in the body is about five hours, 25 percent is excreted unchanged by the kidney, and the remainder is metabolized to lactic acid and pyruvic acid. As already mentioned, propylene masterskaya glycol substance osmotically active. these facts explain the occurrence of some toxic effects of propylene glycol. Among the most significant are the development of lactic acidosis and hyperosmolar coma. has been shown that propylene glycol at toxic dose may be increased masterskaya serum osmolality of 60-80 mmol / l, which itself can lead to the development masterskaya of hyperosmolar coma. Hyperosmolatické serum and lactic masterskaya acidosis can be doprovádzaná central nervous system depression, acute encephalopathy, convulsions and coma and development (see above), or even acute kidney failure, as described for example in a patient treated with parenteral preparation vitamínmy containing propylene glycol. Described boluses also cardiac arrhythmias that occurred in pediatric patients treated with oral medications containing propylene glycol. Similar toxic effects masterskaya were also observed in other studies in conjunction with other symptoms such as hypotension, masterskaya respiratory problems and seizures. Disability masterskaya kidney, and pathogenetics masterskaya if not quite explicitly masterskaya explained, occurs too often in the range of toxic effects of propylene glycol. This involvement has been described in connection with the development of acute renal failure, renal failure masterskaya or nephrotic syndrome. between local, but very unpleasant adverse effects occurring in the parenteral administration of some products containing propylene glycol include masterskaya local damage to the endothelium of blood vessels accompanied by significant masterskaya soreness at the injection site preparation. Specific side effects include oto-toxicity following administration of ear drops, which may significantly limit the use of some specific preparations. All of these side effects have also been studied in animal models and results of these studies are quite consistent with the occurrence of adverse masterskaya effects in humans. V